Intermolecular Interactions between Hsp90 and Hsp70
نویسندگان
چکیده
منابع مشابه
The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex.
The highly coordinated interactions of several molecular chaperones, including hsp70 and hsp90, are required for the folding and conformational regulation of a variety of proteins in eukaryotic cells, such as steroid hormone receptors and many other signal transduction regulators. The protein called Hop serves as an adaptor protein for hsp70 and hsp90 and is thought to optimize their functional...
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Molecular chaperones and their co-chaperones are crucial for the facilitation of efficient protein folding, and prevention of denaturation and aggregation of nascent polypeptides. Hsp70/Hsp90 organizing protein (Hop), a co-chaperone of the two major molecular chaperones, heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90), facilitates their interaction by acting as an adaptor betwee...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2019
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2019.05.026